Search
Close
Search
Advanced Search
Search Menu
AI Discovery Assistant

Abstract

The aim was to compare in a randomized, prospective, parallel-group design the effects of Trandolapril / Verapamil (T/V) and Enalapril / Furosemida (E/F) (both in combination) on renal function in 118 (61-51,7% males) essential hypertensives with a mean age 68,3± 6,2 years, and renal (nephrosclerosis) impairment (mean serum creatinine:1,85±0,41 mg/dl)for a 1-year period.At inclusion demographic and clinical characteristics as well as residual renal function and proteinuria of the patients were similar in both groups, except for mean BPs that were significantly higher in T/V group (n-60) with respect to E/F group (n-58)(p< 0,01). After 2-week wash-out period, the patients started either with T. 2 mg plus V. 180 mg or E. 20 mg plus F. 40 mg OD. One month later, those uncontrolled pts(BP≥ 140/90 mmHg) added increased doses (From 2 mg OD) Doxazosin up to reach BP control. BP decreased in T/V group from 170,4±13 / 97,1± 6 to 138,3±82,2±5 mmHg.(Systolic and Diastolic decrements (mmHg): - 32,13/-14,93), while in E/F group decreased from 162,9±11/94,1±5 to 138±7/80,3±7 mmHg. (Decrements: - 24,88/-13,8 mmHg) . H.R. remained unchanged in E/F group (From 75,6±13 to 72±6 b/min) while significantly decreased (p< 0,01) in T/V group (From 77±10 to 72±6 b/min). BMI remained unchanged in both groups. At the end of 1 year follow-up 51(85%) pts in T/V group and 52 (89,6%) pts in E/F reached a BP < 140/90 mmHg. 40 (66,7) pts reached BP control with T/V and the rest (33,3%) needed to add Doxazosin (mean dose: 3,8 mg OD) while the E/F combination controlled 26 (44,8%) pts (p < 0.05), needing Doxazosin (55,2%)(mean dose: 5,1 mg OD (p< 0,05)). Nevertheless only 33,3 % and 29,3 % pts in the respective groups had a BP < 130/85 mmHg. Mean serum creatinine changed from 1,82±0,36 to 1,80±,61 in TV group and from 1,88±0,5 to 1,91±0,67 (ns) in E/F group and proteinuria from 0,46±0,53 to 0,41±0,48 (ns), and 0,56±0,72 to 0,54±0,58 g/24h (ns) in both groups respectively. Glucose(0,05), Uric Acid(0,01) and LDL-c (0,001) decreased significantly in T/V group. Both groups showed a good clinical tolerability (3 pts in each group withdrew the study). Although there was a tendency to a better changes in renal function parameters and proteinuria with /TV, nevertheless the changes were not statistically significant with both therapeutic regimens. Treatment with T/V showed a significantly greater reduction in SBP and a better beneficial effects on metabolic parameters than that of patients treated with E/F effects.

Elderly, Kidney, Hypertension
This content is only available as a PDF.
© American Journal of Hypertension, Ltd. 2001
Topic:
Issue Section:
Abstracts
You do not currently have access to this article.
Download all slides