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M. V. Ivanov, P-162: Renal function determinants in pts with severe essential hypertension (SEH) complicated by different target-organs damage, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 84A, https://doi.org/10.1016/S0895-7061(01)01807-6
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Abstract
In order to elucidate risc factors in the development and progression of renal function damage 8Ipts with different complications of SEH were studied: Igr.-residual signs of ishemic stroke (IS), n=27; IIgr.-postinfarct cardiosclerosis (PC), n=27; IIIgr.-mild chronic renal failure (CRF) n=27.35 normal men were controls. Renal function assessed by means of Pcr, GFR, CI, Tc-DTPA mean parenchimal transit time (MP TT, sec) from renogram deconvolution. Pelvic MTT assessed as urodynamic index (UI). Relationship between renal function indexes with different factors calculated by correlation analysis. Positive correlations were found between MPTT and UI in all pts with maximum in IIIgr. In Igr. there were positive correlations MPTT with DBP, MBP and GFR, CI with EF in the presence of negative relation MPTT with EF, UI, UA. In IIgr. positive correlations were found between MPTT and age, BMI, Pcr with BMI, UI, MBP. In IIIgr. there were negative correlations between MPTT and EF, GFR. UAE had positive relations with Pcr, UI, BMI, LDL+VLDL. In summary, high DBP, MBP unfavourably influenced on renal function and UI in SEH+IS, PC. Increased UI is common unfavourable factor for renal function in SEH. Proteinuria is significant factor worsening renal function in mild CRF and obesity with hyperlipidemia aggravate it. EF supports renal function in SEH+CRF.