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Pavel J. Levy, Carla Yunis, John Owen, Ronald D. Smith, Carlos M. Ferrario, P-150: Polymorphisms in MTHFR, ACE and AGT genes in hypertensive patients with premature atherosclerosis, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 80A, https://doi.org/10.1016/S0895-7061(01)01759-9
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Abstract
Younger adults with multiple cardiovascular risk factors (CVRF) are at greater risk for premature peripheral atherosclerosis (PASO). We conducted a prospective evaluation of the association between hypertension and the 677C→T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene, the I/D polymorphism in angiotensin converting enzyme (ACE) gene, and the A/G polymorphism in the angiotensinogen (AGT) gene in 92 patients (43% females, 84% white) ≤ 55 years of age (mean 45 yrs) with severe PASO. Forty-three hypertensive patients (44% females; Group A) were compared to 49 normotensive subjects (43% females; Group B). Patients in both groups had similar profile of CVRF, however Group A subjects had higher frequencies of dyslipidemia (79% vs 57%, P=0.03), familial premature CV disease (65% vs 39%, P=0.02) and clinical systemic atherosclerosis [sys-ASO; > 1 anatomic location] (74% vs 41% P=0.002). The Table below summarizes the genetic profile of the subjects.
| . | MTHFR . | ACE/DI . | ACE/DD . | AGT/AG . | AGT/GG . | AGT/AA . |
|---|---|---|---|---|---|---|
| Group A | 23(53) | 23(58) | 13(30) | 13/40(33)* | 15(38)* | 12(28) |
| Group B | 24(49) | 26(53) | 19(39) | 30/44(68) | 6(14) | 8(18) |
| . | MTHFR . | ACE/DI . | ACE/DD . | AGT/AG . | AGT/GG . | AGT/AA . |
|---|---|---|---|---|---|---|
| Group A | 23(53) | 23(58) | 13(30) | 13/40(33)* | 15(38)* | 12(28) |
| Group B | 24(49) | 26(53) | 19(39) | 30/44(68) | 6(14) | 8(18) |
P<0.05
| . | MTHFR . | ACE/DI . | ACE/DD . | AGT/AG . | AGT/GG . | AGT/AA . |
|---|---|---|---|---|---|---|
| Group A | 23(53) | 23(58) | 13(30) | 13/40(33)* | 15(38)* | 12(28) |
| Group B | 24(49) | 26(53) | 19(39) | 30/44(68) | 6(14) | 8(18) |
| . | MTHFR . | ACE/DI . | ACE/DD . | AGT/AG . | AGT/GG . | AGT/AA . |
|---|---|---|---|---|---|---|
| Group A | 23(53) | 23(58) | 13(30) | 13/40(33)* | 15(38)* | 12(28) |
| Group B | 24(49) | 26(53) | 19(39) | 30/44(68) | 6(14) | 8(18) |
P<0.05
MTHFR mutation was more prevalent in subjects with sys-ASO in both groups (P=0.004). Hypertensive patients with sys-ASO (n=32) had greater frequency of AGT/GG when compared to normotensive individuals with sys-ASO (n=29) (37% vs 10% respectively, P<0.05).
Hypertensive patients with premature peripheral atherosclerotic disease had significantly greater frequency of systemic atherosclerosis. AGT/GG genotype was specifically associated with hypertension in these patients. Grant/Research Support: Bristol-Myers, Squibb Speakers' Bureau: Sanofi; BMS; Aventis
