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Myron H. Weinberger, Naomi S. Fineberg, Morris Weinberger, S.Edwin Fineberg, O-16: The relationships between age, gender and blood pressure and vascular compliance and resisitance in normal and hypertensive humans, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 6A, https://doi.org/10.1016/S0895-7061(01)01333-4
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Abstract
To evaluate factors influencing vascular compliance and resistance we utilized the HDI plethysmographic technique to measure pulse wave velocity and estimate vascular compliance and resistance in 275 normal (N) and hypertensive (H) subjects ranging in age from 33 to 80 years.
As expected, we found a significant (p<0.001) decrease in large (C1) and small vessel (C2) compliance and an increase in vascular resistance (R) and impedance (I) in (H) and with age and female gender, but not race, in both groups. Multiple regression analysis showed that age, gender, mean arterial and pulse pressure correlated highly with C1 (p<0.001) in H and that age, gender, systolic pressure and body mass index correlated (P<0.001) with C2 in both H and N. Similar relationships were seen with R and I in both groups. The relationships were stronger for H than for N in all measures. The variables identified accounted for 39% of the variability of C1, 42% of C2, 61% of R and 48% of I in H and less powerful relationships in N.
These findings confirm previous observations demonstrating differences in large and small vessel compliance in H and identify important roles for age, gender, body mass index and pulse pressure which must be considered in similar studies in both normal and hypertensive subjects.
