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Abstract

The aim of this study was to evaluate the effects of magnesium (Mg) on endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation (EIDV).

Nine healthy students, aged 21-29 years, BMI 22.8(SD 2.5) participated in the study. EDV, defined as the absolute forearm blood flow (FBF) value, measured by venous occlusion pletysmography, obtained during infusion with metacholine (MCh), and EIDV, defined as the absolute FBF value obtained during infusion with sodium nitroprusside (SNP), were assessed before and during intra-arterial (brachial artery) Mg infusion, 0.06 mmol/min. The ionized Mg concentrations in plasma were measured by an ion-selective electrode (KONE microlyte).

Venous plasma ionized Mg concentration in the infused arm increased from 0.59(SD 0.04) mmol/L to 1.26(SD 0.34) mmol/L, i.e. by 114% (p=0.0002) FBF at baseline, i.e. before the administration of MCh or SNP, increased from 3.5(SD 1.1) to 7.3(SD 3.4) ml/min/100 ml tissue, i.e. by 109% (p=0.002) during Mg infusion. During Mg infusion the FBF increment during low-dose MCh (2 microg/min) administration increased from 15.4(SD 5.5) to 19.1(SD 6.8), i.e. by 24% (p=0.04), and from 20.3(SD 6.4) to 24.0(SD 7.2), i.e. by 18% (p=0.04) during high dose MCh (4 microg/min) administration. The changes in EIDV during Mg infusion did not reach statistical significance. The systemic blood pressure did not change during the Mg infusion.

Conclusion: Intra-arterial magnesium infusion increased endothelium-dependent vasodilation.

endothelium, magnesium, metacholine
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© American Journal of Hypertension, Ltd. 2001
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