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Branko K. Lovic, Ivan S. Tasic, Stevan B. Ilic, Dragan B. Djordjevic, Marina A. Deljanin-Ilic, Natasa L. Miladinovic-Tasic, P-57: Regression of left ventricular hypertrophy and blood pressure, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 48A, https://doi.org/10.1016/S0895-7061(01)01535-7
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Abstract
It is known that 24 hour ambulatory blood pressure (ABPM) is better correlated with left ventricular hypertrophy (LVH) in hypertension than office BP. However, it is less known what the relation between regression LVH and changes and regulation of BP is.
73 patients with II-III stage hypertension (43 male) average age 55.9 ±8 and LVH determinated by echocardiography has been treated for a year. BP was ambulatory measured and 24-hour ABPM before the start of the research, after 6 months and the end of the research.
Regression of LVH shown in LV mass index decrease is significantly correlated with the change of BP registered 24 hour AMBP. Significant correlation was determined by average 24 hour SBP (R=0.3; p<0.05) decrease, average night SBP (R=0.34; p<0.05)decrease and maximal morning SBP (R = 0.31; p<0.05)decrease.
These results show that BP change measured in 24 hour AMBP is a better predictor of LVH regression than office BP change. (See Table)
| Parameters . | At the start . | After 6 months . | After 12 months . | F test . |
|---|---|---|---|---|
| LVMI (g/m2) | 163 ± 32 | 154 ± 29 | 150 ± 27 | 3.31* |
| SBP office | 168 ± 26 | 159 ± 21 | 158 ± 21 | 3.51* |
| DBP office | 102 ± 13 | 97 ± 12 | 97 ± 11 | 3.69* |
| SBP (24h) | 147 ± 15 | 136 ± 15 | 141 ± 14 | 8.42** |
| DBP (24h) | 91 ± 11 | 85 ± 11 | 87 ± 10 | 7.45** |
| SBP day | 150 ± 16 | 139 ± 16 | 144 ± 15 | 8.74** |
| DBP day | 94 ± 11 | 87 ± 11 | 89 ± 10 | 7.67** |
| SBP night | 137 ± 17 | 128 ± 17 | 132 ± 15 | 5.95* |
| DBP night | 84 ± 12 | 77 ± 12 | 80 ± 11 | 5.55* |
| Parameters . | At the start . | After 6 months . | After 12 months . | F test . |
|---|---|---|---|---|
| LVMI (g/m2) | 163 ± 32 | 154 ± 29 | 150 ± 27 | 3.31* |
| SBP office | 168 ± 26 | 159 ± 21 | 158 ± 21 | 3.51* |
| DBP office | 102 ± 13 | 97 ± 12 | 97 ± 11 | 3.69* |
| SBP (24h) | 147 ± 15 | 136 ± 15 | 141 ± 14 | 8.42** |
| DBP (24h) | 91 ± 11 | 85 ± 11 | 87 ± 10 | 7.45** |
| SBP day | 150 ± 16 | 139 ± 16 | 144 ± 15 | 8.74** |
| DBP day | 94 ± 11 | 87 ± 11 | 89 ± 10 | 7.67** |
| SBP night | 137 ± 17 | 128 ± 17 | 132 ± 15 | 5.95* |
| DBP night | 84 ± 12 | 77 ± 12 | 80 ± 11 | 5.55* |
p<0.05;
p<0.01;
LVMI:LV mass index; SBP:systolic BP, DBP: diastolic BP
| Parameters . | At the start . | After 6 months . | After 12 months . | F test . |
|---|---|---|---|---|
| LVMI (g/m2) | 163 ± 32 | 154 ± 29 | 150 ± 27 | 3.31* |
| SBP office | 168 ± 26 | 159 ± 21 | 158 ± 21 | 3.51* |
| DBP office | 102 ± 13 | 97 ± 12 | 97 ± 11 | 3.69* |
| SBP (24h) | 147 ± 15 | 136 ± 15 | 141 ± 14 | 8.42** |
| DBP (24h) | 91 ± 11 | 85 ± 11 | 87 ± 10 | 7.45** |
| SBP day | 150 ± 16 | 139 ± 16 | 144 ± 15 | 8.74** |
| DBP day | 94 ± 11 | 87 ± 11 | 89 ± 10 | 7.67** |
| SBP night | 137 ± 17 | 128 ± 17 | 132 ± 15 | 5.95* |
| DBP night | 84 ± 12 | 77 ± 12 | 80 ± 11 | 5.55* |
| Parameters . | At the start . | After 6 months . | After 12 months . | F test . |
|---|---|---|---|---|
| LVMI (g/m2) | 163 ± 32 | 154 ± 29 | 150 ± 27 | 3.31* |
| SBP office | 168 ± 26 | 159 ± 21 | 158 ± 21 | 3.51* |
| DBP office | 102 ± 13 | 97 ± 12 | 97 ± 11 | 3.69* |
| SBP (24h) | 147 ± 15 | 136 ± 15 | 141 ± 14 | 8.42** |
| DBP (24h) | 91 ± 11 | 85 ± 11 | 87 ± 10 | 7.45** |
| SBP day | 150 ± 16 | 139 ± 16 | 144 ± 15 | 8.74** |
| DBP day | 94 ± 11 | 87 ± 11 | 89 ± 10 | 7.67** |
| SBP night | 137 ± 17 | 128 ± 17 | 132 ± 15 | 5.95* |
| DBP night | 84 ± 12 | 77 ± 12 | 80 ± 11 | 5.55* |
p<0.05;
p<0.01;
LVMI:LV mass index; SBP:systolic BP, DBP: diastolic BP
