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Abstract

Purpose:

Hiperaldostoronism in adrenal adenoma is a curable cause of secondary high blood pressure (HBP). Primary hiperaldosteronism characterised by raised values of serum aldosterone with blunted ranine levels in patients with adrenal adenoma was until now usually treated by open surgery or more recently by video-laparoscopy. These invasive therapies are frequently associated with complications and are more aggressive, much more expensive and time consuming when compared with the CT-guided percutaneous ethanol injection (PEI). The aim of this study is the evaluation of ethanol induced ablation of adrenal adenomas in secondary HBP.

Materials and Methods:

PEI is a sclerosing technique already used for the ablation of tumours.

With previous consent of the Ethical Commission of our Hospital, we performed CT-guided PEI in 34 patients (13 male and 21 female) for the ablation of functioning adrenal adenomas diagnosed by CT. Patients were released after 72 hours. All patients were submitted to a new hormonal and imagiologic study 6 months after PEI.

Results:

The series submitted to surgical treatment was considered for evaluation as the «golden standard». In 72% of the patients we achieved normal blood pressure 48 to 72h after PEI. Clinically controlled examinations confirmed that in 67% of the patients we achieved normal blood pressure (≤139/ 89 mm Hg). The hormonal levels tend also to be normal.

Conclusion:

Preliminary results for this technique are most promising and definitely as good as those obtained with surgical treatment.

Ethanol Injection, Adrenal Adenomas, Ablation
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© American Journal of Hypertension, Ltd. 2001
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