Abstract

Elevated serum uric acid (UA) and creatinine (Cr) are predictors of CV risk. The relation among both parameters could question the prognostic value of UA in favor of the presence of mild renal insufficiency.

Our objective was to assess the correlation between UA and renal function and hypertension severity in a cohort of 1274 patients aged 35 to 60-y with essential hypertension diagnosed at a University Hospital. Disease severity ranged from 1 to 6, according to blood pressure levels and target organ damage.

UA levels showed a positive association with severity of hypertension, dyslipemia, male gender and Cr, being the last one the strongest (r=0,49, P<0,001). In fact, Cr values were 0,94 (0,23) mg/dl (mean (SD)) and 1,33 (0,74) in patients with UA levels ≤7 and >7 respectively (p<0,01). Disease severity was higher in hyperuricemic (2.28 (1.20) points) than in normouricemic (1.96 (1.06); p<0.05). A multivariate analysis, showed that Cr but not UA levels remained as an independent predictor of hypertension severity.

Hyperuricemia is related to hypertensive renal damage. Therefore, the usefulness of serum urate as a marker of risk is jeopardized by the highest predictive value of mild renal insufficiency.

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