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Abstract

[Purpose] Oxidative stress plays an important role in the pathogenesis of vascular injury and in the progression of atherosclerosis. Elevated levels of oxidized low density lipoprotein (OxLDL) have been reported to be a risk factor for coronary artery disease. We investigated the potential association between circulating OxLDL levels and left ventricular hypertrophy in patient with essential hypertension.

[Methods] Thirty hypertensive patients ( 14 men and 16 women, mean age, 63years) were enrolled in this study. Left ventricular hypertrophy was evaluated with M-mode echocardiographic measurements of the left ventricle, as left ventricular mass index (LVMI). Common carotid artery vascular mass (VM) was also calculated as ( ρLπ { (CAD/2+IMT)2(CAD/2)2} ). CAD: vessel diameter of the common carotid artery, IMT: intima-media thickness ). Circulating OxLDL levels were measured by an enzyme immunoassay with use of specific antibodies against OxLDL ( FOH1a / DLH3 ) and apolipoprotein B.

[Results] Circulating OxLDL levels were significantly higher in hypertensive patients with left ventricular hypertrophy than in those without left ventricular hypertrophy ( LVH 28.0±9.7 U/ml, non-LVH 21.5±9.0 ; p=0.03 ). Multiple regression analysis showed that the risk factors for LMVI in patients with essential hypertension were circulating OxLDL levels and VM. (p=0.01)

[Conclusions] These results indicate that circulating OxLDL levels may be an independent risk factor for left ventricular hypertrophy in patients with essential hypertension.

oxidized low density protein, left ventricular hypertrophy, carotid artery vascular mass
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© American Journal of Hypertension, Ltd. 2001
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