-
Views
-
Cite
Cite
Daniela Degli Esposti, Angelo Ghirardini, Maria Rosa Pugliese, Paolo Mazzetti Gaito, Nicola Venturoli, Marzia Monti, Alessandro Nanni Costa, Flavia Petrini, Gerardo Martinelli, Lorenza Ridolfi, P-533: Hypertension, left ventricular hypertrophy and organ suitability to transplantation in potential donors, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 209A, https://doi.org/10.1016/S0895-7061(01)01798-8
Close - Share Icon Share
Abstract
Target organ damage in hypertensive organ donors can result in a less percentage of transplanted organs. Organ suitability to transplantation could be viewed as a peculiar expression of target organ damage in high cardiovascular risk potential donors. In a potential donors population we evaluated the organ suitability to transplantation respect to cause of death, the presence of high blood pressure (HBP) and the presence of documented target organ damage, such as left ventricular hypertrophy (LVH). In a three year period we evaluated the number of transplanted organs of a potential donors pool coming from a population of about 18 millions inhabitants. Among 899 potential donors (583 M, 361 F, mean age 48 yrs, range 0-88), anamnestic HBP was referred in 229 (25%). The cause of death was cerebrocardiovascular accidents (CCV) in 535 (51%) and non-vascular events (NV) in 364 (49%). 455 subjects (285 M, 160 F, mean age 38 yrs, range 0-69) were submitted to echocardiography; LVH was found in 78 (17%). The organs utilization is represented in the table (*,**,° = p<.01 vs no LVH, NV, no HBP).
| . | Kidney . | heart . | liver . | lung . |
|---|---|---|---|---|
| HBP (229) | 64% | 8%° | 92% | 3% |
| No HBP (670) | 79% | 44% | 86% | 9% |
| LVH (78) | 86% | 26%* | 91% | 6% |
| No LVH | 89% | 68% | 92% | 12 |
| CCV (535) | 71% | 22%** | 83% | 6% |
| No CCV (364) | 82% | 56% | 88% | 9% |
| . | Kidney . | heart . | liver . | lung . |
|---|---|---|---|---|
| HBP (229) | 64% | 8%° | 92% | 3% |
| No HBP (670) | 79% | 44% | 86% | 9% |
| LVH (78) | 86% | 26%* | 91% | 6% |
| No LVH | 89% | 68% | 92% | 12 |
| CCV (535) | 71% | 22%** | 83% | 6% |
| No CCV (364) | 82% | 56% | 88% | 9% |
| . | Kidney . | heart . | liver . | lung . |
|---|---|---|---|---|
| HBP (229) | 64% | 8%° | 92% | 3% |
| No HBP (670) | 79% | 44% | 86% | 9% |
| LVH (78) | 86% | 26%* | 91% | 6% |
| No LVH | 89% | 68% | 92% | 12 |
| CCV (535) | 71% | 22%** | 83% | 6% |
| No CCV (364) | 82% | 56% | 88% | 9% |
| . | Kidney . | heart . | liver . | lung . |
|---|---|---|---|---|
| HBP (229) | 64% | 8%° | 92% | 3% |
| No HBP (670) | 79% | 44% | 86% | 9% |
| LVH (78) | 86% | 26%* | 91% | 6% |
| No LVH | 89% | 68% | 92% | 12 |
| CCV (535) | 71% | 22%** | 83% | 6% |
| No CCV (364) | 82% | 56% | 88% | 9% |
Transplanted organs in high or low cardiovascular risk potential donors
No significant differences were observed between subjects with high (HBP, LVH, CCV death) or low cardiovascular risk in terms of organs utilization for transplantation, apart from the heart, frequently involved by LVH in high cardiovascular risk potential donors. Therefore, in this selected young population, the first organ to be damaged in HBP seems to be the heart, without any substantial damage to other organs, for example the kidney.
