Abstract

Epidemiological data indicate that pulse pressure (PP) is a strong predictor of cardiovascular complications. However, correlates of PP in-patients with hypertensive LVH have not been adequately studied.

We examined baseline data form 9,189 patients with hypertension and ECG LVH participating in the Losartan Intervention For End Points (LIFE) Trial. Patients were grouped as follows: PP <53 (Gr. 1,n=625), 54-63 (Gr. 2, n=1073), 64-77 (Gr. 3, n=2857) and >77 mm Hg (Gr. 4, n=4634).

There was a strong positive association with several CVS risk factors and pp (table).

Correlates of Pulse Pressure (pp)
Gr1Gr2Gr3Gr4p-Value
Age (years)63646669<.000
Systolic BP (mm Hg)147161170184<.000
Cholest mmol5.936.016.026.08<.007
Glucose mmol5.785.925.886.16<.000
*UMA (mg/dl)47.753.255.275.4<.000
**UACR4.96.45.99.5<.000
LVMI (*g/m2)116121124125<.025
LVMH2.752555657<.007
Correlates of Pulse Pressure (pp)
Gr1Gr2Gr3Gr4p-Value
Age (years)63646669<.000
Systolic BP (mm Hg)147161170184<.000
Cholest mmol5.936.016.026.08<.007
Glucose mmol5.785.925.886.16<.000
*UMA (mg/dl)47.753.255.275.4<.000
**UACR4.96.45.99.5<.000
LVMI (*g/m2)116121124125<.025
LVMH2.752555657<.007
*

Urine microalbumine;

**

urine albumine/creatinine ratio

Correlates of Pulse Pressure (pp)
Gr1Gr2Gr3Gr4p-Value
Age (years)63646669<.000
Systolic BP (mm Hg)147161170184<.000
Cholest mmol5.936.016.026.08<.007
Glucose mmol5.785.925.886.16<.000
*UMA (mg/dl)47.753.255.275.4<.000
**UACR4.96.45.99.5<.000
LVMI (*g/m2)116121124125<.025
LVMH2.752555657<.007
Correlates of Pulse Pressure (pp)
Gr1Gr2Gr3Gr4p-Value
Age (years)63646669<.000
Systolic BP (mm Hg)147161170184<.000
Cholest mmol5.936.016.026.08<.007
Glucose mmol5.785.925.886.16<.000
*UMA (mg/dl)47.753.255.275.4<.000
**UACR4.96.45.99.5<.000
LVMI (*g/m2)116121124125<.025
LVMH2.752555657<.007
*

Urine microalbumine;

**

urine albumine/creatinine ratio

There was also a linear but negative association of PP with height, weight, hemoglobin level and diastolic BP (all <0.000)

Conclusions:

In hypertensive patients with ECG LVH PP is strongly associated with the major CVS risk factors such as age, systolic BP, serum cholesterol and glucose, microalbuminuria and degree of LVH. These associations may in part explain the predictive value of PP on cardiovascular outcomes.

This content is only available as a PDF.
You do not currently have access to this article.