Search
Close
Search
Advanced Search
Search Menu
AI Discovery Assistant

Abstract

Stiffness Index (SI) is an effective parameter for estimating mineralization of trabecular bone related to Calcium metabolism. Moreover, antihypertensive drugs, especially diuretics, can interfere with Calcium metabolism. The purpose of this study was to assess SI in patients (pts) with normal blood pressure (NBP) - <140/80 mmHg-, and hypertensive pts with and without antihypertensive therapy. Study population undergone heel ultrasonography to measure SI: 209 pts, 36 males (17%) and 173 females (87%), age from 39 to 79 years. They were divided into three groups. 1. Pts with NBP: 85 (41%), 12 males (14%) and 73 females (86%), with a mean age of 55+/-12 years, mean BP of 119(+/-9)/74(+/-8) mmHg, and mean SI of 89+/-17. 2. Pts with untreated hypertension: 70 (33%), 19 males (27%) and 51 females (73%), with a mean age of 56+/-11 years, mean BP of 148(+/-21)/89(+/-9) mmHg, and mean SI of 75+/-17. 3. Hypertensive pts under therapy (Beta-blockers 17, Calcium channel antagonists 11, Angiotensin-converting enzyme inhibitors 24, Diuretics 22): 54 (26%), 5 males (9%) and 49 females (91%), with a mean age of 61+/- 9 years, mean BP of 150(+/-18)/92(+/-6.5) mmHg, and mean SI of 80+/-19. Statistical analysis (t-test, P <0.05 statistically significant) showed that there was a statistically significant difference (P<0.01) between NBP pts and hypertensive pts for SI and age with a major evidence for untreated pts. In conclusion, SI would be reduced in hypertensive pts, especially without antihypertensive therapy, who could undergo earlier to age related osteoporosis.

Bone, Calcium, Blood Pressure
This content is only available as a PDF.
© American Journal of Hypertension, Ltd. 2001
Topic:
Issue Section:
Abstracts
You do not currently have access to this article.
Download all slides