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C. Calvo, J. E. López, M. Covelo, M. J. Domıénguez, C. Martıénez, D. E. Ayala, R. C. Hermida, P-431: Effects of sildenafil on blood pressure in hypertensive patients with erectile dysfunction, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 176A, https://doi.org/10.1016/S0895-7061(01)01603-X
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Abstract
Erectile dysfunction (ED) is common among hypertensive men, associated to hypertension itself and/or as a consequence of antihypertensive treatment. Accordingly, we evaluated the efficacy and safety of Sildenafil (PDE5 inhibitor) and its effects on blood pressure (BP) in hypertensive men with ED. We studied 23 men with previously-diagnosed essential hypertension, 55±6 (mean±SD) years of age, receiving 1-2 drugs for hypertension, and with diagnosis of ED determined by the Sexual Health Inventory for Men (SHIM) and the International Index of Erectile Function (IIEF). ED is defined as a punctuation below 21/26 for SHIM/IIEF. After diagnosis of ED, 50 mg Sildenafil were prescribed to be administered 60 minutes before sexual intercourse. BP was sampled with an Spacelabs 90207 device for 24 hours before and on the same day of treatment with Sildenafil. Efficacy was evaluated by application of new SHIM and IIEF questionnaires after treatment. Safety was evaluated by analysis of adverse events reported by the patients. Only 4 patients (17%) presented mild transient adverse effects, and 17 patients (74%) improved from their ED. Results also indicate a statistically significant reduction in the nocturnal mean of systolic BP (127±9 to 120±12 mmHg; P<0.05) and increase in the nocturnal mean of heart rate (HR) (67±8 to 71±8 beats/minute; P<0.05). Administration of Sildenafil is highly efficient and well tolerated in hypertensive patients with ED. Moreover, Sildenafil does not modify the diurnal BP mean, although decreases the nocturnal systolic BP while increasing the nocturnal HR.
Support: DGES, PM98-0106; Vic. Investigación, Univ. Vigo.