-
Views
-
Cite
Cite
Dirk C. Felmeden, Charles G. C. Spencer, Funmi Belgore, Andrew D. Blann, Gareth D. Beevers, Gregory Y. H. Lip, P-412: Relationship of von Willebrand factor, an index for endothelial damage, and vascular endothelial growth factor, an index of angiogenesis to cardiovascular and cerebrovascular risk scores based on the framingham equation, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 169A, https://doi.org/10.1016/S0895-7061(01)01570-9
- Share Icon Share
Abstract
Hypertensive patients are at particular risk of thrombotic and atherosclerotic complications. Endothelial damage and abnormal angiogenesis play an important role in precipitating these thrombotic events. We analysed plasma levels of von Willebrand factor (vWF, a marker for endothelial damage) and vascular endothelial growth factor (VEGF, an index of angiogenesis) using ELISA methods in 177 consecutive hypertensives (130 male, mean age 62 (SD8) years) and 21 controls (11 male, mean age 58 (SD5) years). Subjects were assessed for cardiovascular risk factors including age, sex, smoking habit, blood pressure, serum cholesterol, left ventricular hypertrophy on ECG, and diabetes mellitus. Using the Framingham risk calculator a coronary heart disease (CHD) and stroke risk score were derived. Risk scores from the combined group were correlated (Spearman's method) with plasma levels of vWF and VEGF. (See Table)
Results . | CHD risk . | . | Stroke risk . | . |
---|---|---|---|---|
. | R . | p-value . | R . | p-value . |
vWF | 0.209 | <0.01 | 0.280 | <0.05 |
VEGF | 0.263 | <0.01 | 0.286 | <0.01 |
Results . | CHD risk . | . | Stroke risk . | . |
---|---|---|---|---|
. | R . | p-value . | R . | p-value . |
vWF | 0.209 | <0.01 | 0.280 | <0.05 |
VEGF | 0.263 | <0.01 | 0.286 | <0.01 |
Results . | CHD risk . | . | Stroke risk . | . |
---|---|---|---|---|
. | R . | p-value . | R . | p-value . |
vWF | 0.209 | <0.01 | 0.280 | <0.05 |
VEGF | 0.263 | <0.01 | 0.286 | <0.01 |
Results . | CHD risk . | . | Stroke risk . | . |
---|---|---|---|---|
. | R . | p-value . | R . | p-value . |
vWF | 0.209 | <0.01 | 0.280 | <0.05 |
VEGF | 0.263 | <0.01 | 0.286 | <0.01 |
Results are presented as correlation coefficient (R) and p-value. Apart from a borderline significant correlation between VEGF and total cholesterol (R=0.189, p=0.046), there was no statistically significant correlations between vWF or VEGF and the individual risk factors. Vascular endothelial growth factor and endothelial damage as assessed by vWF are correlated with the cerebrovascular and coronary heart disease risk according to the Framingham equation. These markers of endothelial damage and angiogenesis might assist in evaluating the cardio- and cerebrovascular risk profile of hypertensive patients.
- angiogenesis
- smoking
- hypertension
- vascular endothelial growth factor a
- diabetes mellitus
- von willebrand factor
- framingham heart study
- heart disease risk factors
- enzyme-linked immunosorbent assay
- left ventricular hypertrophy
- blood pressure
- cardiovascular system
- endothelium
- habits
- plasma
- thrombus
- coronary heart disease
- coronary heart disease risk
- serum cholesterol measurement
- stroke risk
- total cholesterol
- framingham risk calculator