Abstract

HGF has many organ protective functions. Our previous data demonstrated that HGF stimulated growth of endothelial and epithelial cells in vitro. Moreover, Ang II and TGF-b significantly decreased local HGF production in endothelial cells. Therefore, we examined the clinical effects of an ACE inhibitor (cilazapril) and β-blocker (atenolol) on hypertensive patients. An ACE inhibitor (cilazapril; 0.5or1.0mg/day) and β-blocker (atenolol; 50or 100mg/day) were administrated to age-matched hypertensive patients for 6 months. Male are 9 and female are 6 persons. All hypotensive drugs were leaved off before trials were stated over 3 months. PWV were measured left carotid and femoral artery by FCP-4731 FUKUDA DENSHI. Serum HGF concentrations were measured by EIA. This study demonstrated that HGF prevented arteriosclerosis. Systolic and diastolic Blood pressure were significantly decreased in cilazapril and atenolol treated groups equally(p<0.01). Moreover, cilazapril significantly was improved PWV and serum HGF concentration. (p<0.01) Of importance, serum HGF production was markedly increased by only cilazapril treatment. Together with a significant improved PWV by cilazapril. The present data demonstrated the regression arteriosclerosis and increased serum HGF production by cilazapril in hypertensive patient. Protective actions of cilazapril on arterial epithelial formation may be partially mediated by increased serum HGF production.

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