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Abstract

Despite important advances in clinical HT, hemodynamics in Systolic HT (SHT) are not fully defined. To assess such changes in SHT we included non-invasive Arterial Waveform Analysis (DynaPulse 200) in all HT subjects. In one year study, 19 (Female n=16, Male n=3, aged 68±11 yr.) out of 235 Hypertensives had SHT (8 %). Non-Invasive Hemodynamic: LVET, dP/dT max, LV Stroke Volume (LVSV), CO, Cardiac work, LV Stroke Work (LVSW), SV Resistance and Compliance, Brachial Artery (BA) Resistance and Compliance, BP,Pulse Pressure (PP) and HR was recoreded at rest, isometric hand grip and 15 min after. RESULTS: a) BP was 192.6±20/ 79.5±7 mmHg; PP: 119±14 and HR 55±12 bbm; b) marked increased LV dP/dT max 1.655±441 mmHg /s, LVET 463.6±34 msc, Contractility index 19.2±5 1/s, Cardiac Work 92.4±18 J/min, and increased aortic stiff index (2.28±0.7 unit) resulted in 2 peak aortic waveform and increased augmentation index (41±9 mmHg); c) increased SV Resistance index 3.208±274 dy.s.cm5, decreased SV compliance (0.81±0.2 ml/mmHg) and brachial artery compliance (0.026±0.026 ml/mmHg) with brachial distensibilty 5.2±0.4 %. Conclusion: The results of this study indicates that SHT represents a severe form of HT, with disturbed arterial structure and vascular resistance, occuring more frequent in women.

Non-invasive hemodynamic, Systolic hypertension, Aortic augmentation index
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© American Journal of Hypertension, Ltd. 2001
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