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L. M. Resnick, M. H. Lester, P-286: Effect of modest weight loss on arterial compliance in essential hypertension, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 124A, https://doi.org/10.1016/S0895-7061(01)01457-1
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Abstract
To investigate the vascular consequences of weight loss, we measured blood pressure, pulse pressure (PP), and large (C1) and small (C2) artery components of compliance by computerized pulse waveform analysis (CAPWA), before and after modest weight loss (196±12 to 185±11 lbs) in 14 essential hypertensive subjects.
Modest weight loss was not associated with significant changes in systolic (146±4 to 138±4 mmHg, p=0.065) or diastolic BP (89 ±4 to 87 ±3 mmHg, p = 0.39), but PP fell significantly (57 ±3 to 51 ±3 mmHg, p=0.012). Both large artery compliance, (C1x10, 14 ±2 to 18 ±2 ml/mmHg, p=0.0039) and small artery compliance (C2x100, 4.4 ±0.9 to 5.6 ±1.1 ml/mmHg, p=0.0073) rose following weight loss.
ΔPP was related to ΔSBP (r = 0.796, p=0.00007) and to the initial weight (r = -0.546, p = 0.04), but not to ΔDBP (r = 0.398, p = NS). The change in PP partly explained ΔC1 (r = -0.566, p = 0.035), but not ΔC2 (r = 0.194, p = NS).
We conclude i) that modest weight loss in essential hypertension increases arterial compliance, ii) that these changes may precede significant changes in blood pressure, and iii) that measurement of blood pressure or pulse pressure is not sufficient to explain weight loss-induced changes in arterial compliance. As such, these data further support the clinical utility of CAPWA-based arterial compliance measurements in assessing the peripheral vasculature in essential hypertension.
