-
Views
-
Cite
Cite
Yoshikuni Yamamoto, Katsuhiko Kohara, Yasuharu Tabara, Michie Ohnishi, Shozo Ueki, Hiromitsu Yano, Michiya Igase, Jun Nakura, Tetsuro Miki, P-278: Plasma level of hepatocyte growth factor is associated with carotid intima-media thickness, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Pages 121A–122A, https://doi.org/10.1016/S0895-7061(01)01449-2
- Share Icon Share
Abstract
Plasma level of hepatocyte growth factor (HGF) has been shown to be associated with severity of hypertension, diabetic retinopathy, or peripheral arteriosclerotic disorders. We investigate whether plasma level of HGF could be used as marker for atherosclerosis. Plasma level of HGF was determined by ELISA in 204 community-dwelling healthy residents free from any medications. Imtima-media thickness (IMT) was measured by ultrasonography with 7.5 MHz probe. Plasma level of HGF was significantly associated with age (p=0.0001), systolic blood pressure (p=0.019), and male sex (p=0.015). However, plasma HGF was not associated with diastolic blood pressure, total-cholesterol, plasma glucose, and smoking. Plasma HGF was significantly associated with carotid IMT (r=0.014). Stepwise regression analysis revealed that carotid atherosclerosis defined as IMT>0.85 mm independently explains plasma level of HGF. Plasma level of HGF≥0.16 ng/ml was independently associated with carotid atherosclerosis in addition to hypertension and male sex. These findings indicate that plasma level of HGF could be used as biohumoral marker for the severity of atherosclerosis.
- atherosclerosis
- smoking
- hypertension
- ultrasonography
- enzyme-linked immunosorbent assay
- systolic blood pressure
- carotid atherosclerosis
- diabetic retinopathy
- hepatocyte growth factor
- internship and residency
- plasma
- plasma glucose
- diastolic blood pressure
- total cholesterol
- medical residencies
- community
- carotid intima-media thickness