Abstract
To evaluate the influence of losartan on some renal parameters, we studied 10 mild and uncomplicated essential hypertensive patients, aged 28 to 70 years (mean 45.2) during placebo treatment and after a 4-month period of therapy with losartan 50 mg once daily. The average serum potassium concentration was only slightly increased during treatment with losartan, but looking at the individual changes, there was a similar trend versus the increase in the majority of our patients, always in the range of the normal values, namely in the patients with lower values in basal conditions. The changes observed in serum potassium were not related to serum creatinine levels and the average (and individual values) of serum creatinine observed in our patients were always in the normal range without any significant modification in comparison to basal values. A slight but significant reduction in uric acid from 5.8±1.4 to 5±1 mg/dl (p<0.01) was also seen. Increase in serum potassium during losartan correlates with reduction in premature ventricular beats(r=0.72) 24-h ecg monitoring. (See Figure)
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© American Journal of Hypertension, Ltd. 2001
