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Anna Vittoria Mattioli, Leonardo Fortanesi, Roberto Vandelli, Lorenzo Bonetti, Giorgio Mattioli, P-261: Regression of left ventricular hypertrophy on serial echocardiography in patients treated with telmisartan, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 116A, https://doi.org/10.1016/S0895-7061(01)02115-X
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Abstract
The aim of the study was to evaluate the effect of telmisartan monotherapy on regress of left ventricular (LV) hypertrophy and LV function in patients (pts) with mild-moderate LV hypertrophy.
We selected 66 pts with mild-moderate LV hypertrophy. Pts population included 43 men and 23 women with a LVMI >116 in men and women <60 years/old, or >104 in older women, and with a mean age of 54 ±9 years. All pts were treated with telmisartan (40 mg=29 pts and 80 mg=37 pts). Serial echocardiography was performed at 1-3-6 and 9 months, so that changes in LVMI (g/m2) and LV function could be related to changes in blood pressure. LV and left atrial function were assessed by Doppler echocardiography: transmitral peak A velocity (A) and integral (Ai), peak E velocity (E),deceleration time (dec t)and isolumic relaxation time (IVRT), left atrial maximal (LA max vol) and minimal volume (LA min vol). All pts had an increased LVMI (220 ± 46). At baseline diastolic function was impaired in all pts: peak E vel was 0,47 ± 0.1 m/sec, peak A vel was 0,80 ± 0.11 m/sec, dec t was 230 ± 34, IVRT was 110 ± 14. There was a weak correlation between changes in LVMI and changes in SBP (r=0.26 p < 0.05) and DBP (r=0.34 p < 0.03).
In conclusion Telmisartan monotherapy progressively decreased blood pressure. Treatment with telmisartan results in significant regression of LV hypertrophy and improvment of diastolic function. Regression of hypertrophy was not strongly correlated to the magnitude of blood pressure reduction. (See Table)
| parameters . | baseline . | 3 months . | 6 months . | 9 months . |
|---|---|---|---|---|
| SBP/DBP | 167/104 | 137/95° | 132/89.5° | 126/86° |
| HR | 77.6±12 | 75±9 | 76±10 | 75±9 |
| LVMI | 117.8±17 | 116.9±12 | 113.8±19 | 106.2±20° |
| LV diast Vol | 126±6 | 124±8 | 123.7±7 | 121±6° |
| LV sist Vol | 66±4 | 65±7 | 64±8 | 62±6° |
| E/A ratio | 0.59 | 0.65 | 0.71 | 0.88° |
| Dec t | 230±34 | 228±27 | 217±21° | 214±21° |
| IVRT | 110±14 | 108±12 | 106±8° | 105±13° |
| parameters . | baseline . | 3 months . | 6 months . | 9 months . |
|---|---|---|---|---|
| SBP/DBP | 167/104 | 137/95° | 132/89.5° | 126/86° |
| HR | 77.6±12 | 75±9 | 76±10 | 75±9 |
| LVMI | 117.8±17 | 116.9±12 | 113.8±19 | 106.2±20° |
| LV diast Vol | 126±6 | 124±8 | 123.7±7 | 121±6° |
| LV sist Vol | 66±4 | 65±7 | 64±8 | 62±6° |
| E/A ratio | 0.59 | 0.65 | 0.71 | 0.88° |
| Dec t | 230±34 | 228±27 | 217±21° | 214±21° |
| IVRT | 110±14 | 108±12 | 106±8° | 105±13° |
p <0.01
| parameters . | baseline . | 3 months . | 6 months . | 9 months . |
|---|---|---|---|---|
| SBP/DBP | 167/104 | 137/95° | 132/89.5° | 126/86° |
| HR | 77.6±12 | 75±9 | 76±10 | 75±9 |
| LVMI | 117.8±17 | 116.9±12 | 113.8±19 | 106.2±20° |
| LV diast Vol | 126±6 | 124±8 | 123.7±7 | 121±6° |
| LV sist Vol | 66±4 | 65±7 | 64±8 | 62±6° |
| E/A ratio | 0.59 | 0.65 | 0.71 | 0.88° |
| Dec t | 230±34 | 228±27 | 217±21° | 214±21° |
| IVRT | 110±14 | 108±12 | 106±8° | 105±13° |
| parameters . | baseline . | 3 months . | 6 months . | 9 months . |
|---|---|---|---|---|
| SBP/DBP | 167/104 | 137/95° | 132/89.5° | 126/86° |
| HR | 77.6±12 | 75±9 | 76±10 | 75±9 |
| LVMI | 117.8±17 | 116.9±12 | 113.8±19 | 106.2±20° |
| LV diast Vol | 126±6 | 124±8 | 123.7±7 | 121±6° |
| LV sist Vol | 66±4 | 65±7 | 64±8 | 62±6° |
| E/A ratio | 0.59 | 0.65 | 0.71 | 0.88° |
| Dec t | 230±34 | 228±27 | 217±21° | 214±21° |
| IVRT | 110±14 | 108±12 | 106±8° | 105±13° |
p <0.01
