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Ioannis G. Styliadis, Nicolaos Lefkos, P-226: Effect of lisinopril in left ventricular systolic and diastolic function in hypertensive patients with left ventricular hypertrophy, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 104A, https://doi.org/10.1016/S0895-7061(01)01416-9
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Abstract
The aim of this study is to evaluated the changes in hypertrophy, systolic and diastolic function of left venticular in hypertensives patients who treated with lisinopril.
20 hypertensive patients (14male, 6 female mean age 52,05+8,23 years) with left ventricular hypertrophy were studied. All patient were treated with 20mg lisinopril for a period 4 months.
An analysis of the trough-to-peak ratio for sitting systolic and diastolic blood pressure revealed values of 0.72 and 0.67. The echocardio-Doppler evaluation was performed both at rest and at the peak of test. Left ventricular dimensions were obtained from two-dimensionally guided M-mode tracings using the criteria of the American Society of Echocardiography. Left ventricular peak filling rates and filling rate integrals were measured by a pulsed Doppler technique. Lisinopril caused a significant reduction in systolic and diastolic blood pressure at rest ( p < 0.05 and p < 0.05) and during exercise (p < 0.05 and p < 0.05). LVEDd, IVS and LV mas index were significant reduced after treatment with lisinopril ( p < 0.05, p < 0.01 and p < 0.01) Ejection Fraction was increased (p<0,01) and end systolic stress decreased (p<0,05) both at rest and during exercise . All the left ventricular filling parameters considered (E velocity, A velocity, E/A ratio) both at rest and during exercise were significantly imroved after lisinopril treatment. This study demonstrates that short-term administation of lisinopril improve left ventricular systolic and diastolic function in of hypertensive patients with LV hypertrophy.
