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Jin Yang, Shigeto Morimoto, P-82: Renin gene MboI site polymorphism is associated with cerebral bleeding in the Japanese elderly, American Journal of Hypertension, Volume 14, Issue S1, April 2001, Page 56A, https://doi.org/10.1016/S0895-7061(01)01593-X
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Abstract
In the present study, we investigated possible association of renin gene MboI site polymorphism with cerebral bleeding in the japanese elderly. Subjects studied were 57 elderly patients with cerebral bleeding diagnosed by CT examination [80±9 years] and 228 age- and sex-matched elderly subjects without cerebrovascular accident (80±9 years). Clinical factors associated with cerebral bleeding with the significant levels of 0.2 were hypertension (p=0.027) and diabetes mellitus (p=0.069). Distributions of renin gene MboI site polymorphism were in Hardy-Weinberg equilibrium in the two groups. The polymorphism was significantly associated with cerebral bleeding by univariate analysis (p=0.012). Logistic regression analysis using age, sex, hypertension and diabetes mellitus as confounding factors revealed that the renin gene MboI site m allele is associated with cerebral bleeding (mm vs. Mm vs. MM: p=0.038, RR=1.92, 95% CI; 1.03-3.57). Moreover, decrease in diastolic blood pressure under salt intake of 14 g/day to 7 g/day was larger with the increasing number of m allele both in the control elderlies (p=0.043) and patients with cerebral bleeding (p=0.031).Our results indicate that renin gene MobI site polymorphism is a genetic risk factor for cerebral bleeding in the japanese elderly.
