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Abstract

Hiperaldosteronism in adrenal adenoma is a curable cause of secondary high blood pressure(HBP). Primary aldosteronism characterised by raised values of serum aldosteron with blunted renine levels in patients with adrenal adenoma was until now usually treated by open surgery or more recently by video-laparoscopy. These invasives therapies are frequently associated with complications and more aggressive, much more expensive and time consuming when compared with the CT guided percutaneous ethanol injection (PEI). The aim of this study is the evaluation of ethanol induced ablation of adrenal adenomas in secondary HBPH

Material and Methods:

PEI is a sclerosing technique already used for the ablations of tumors.

With previous consent of the Ethical Commission of our Hospital we performed CT-guided PEI in 34 patients (13 males and 21 females) for the ablation of functioning adrenal adenomas, diagnosed by CT. Patients were released after 72 hours.All patients were submitted to a new hormonal and imagiologic study 6 months after PEI.

Results:

The series submitted to surgical treatment was considered for evaluation as the “golden standard”. In 72% of the patients we achieved normal blood pressure 48 to 72 h after PEI. Control examinations (6 months after) confirmed that in 67% of the patients we achieved normal blood pressure (< 139/89 mmhg) and clinically we got an absence of the major symptoms due to hiperaldosteronisme (easy fatigue,caimbras,...). The hormonal levels tend also to be normal.

Conclusion:

Preliminary results for this technique are most promising and defenitly as good as those obtained with surgical treatment.

renine, aldosterone, primary aldosterone
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© American Journal of Hypertension, Ltd. 2001
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